منابع مشابه
Spermidine Biosynthesis in Saccharomyces cereuisiae
We have cloned and sequenced the Saccharomyces cerevisiae gene for S-adenosylmethionine decarboxylase. This enzyme contains covalently bound pyruvate which is essential for enzymatic activity. We have shown that this enzyme is synthesized as a M, 46,000 proenzyme which is then cleaved post-translationally to form two polypeptide chains: a fi subunit (Mr 10,000) from the amino-terminal portion a...
متن کاملSpermidine biosynthesis and transport modulate pneumococcal autolysis.
Polyamines are small cationic molecules that have far-reaching roles in biology. In the case of pathogenic bacteria, these functions include those central to their pathogenesis. Streptococcus pneumoniae is a major bacterial pathogen, causing a diverse range of diseases that account for significant morbidity and mortality worldwide. In this work, we characterize the polyamine biosynthetic pathwa...
متن کاملA new pathway for the biosynthesis of spermidine.
The only pathway known for the biosynthesis of sperrnidine is from putrescine and S-adenosylmethionine. S-Adenosylmethionine is decarboxylated, and the aminopropyl group of the product is transferred to putrescine to form spermidine. The enzymes of this pathway, S-adenosylmethionine decarboxylase (EC 4.1.1 S O ) and aminopropyltransferase (EC 2.5.1.16), have been found in a number of bacteria, ...
متن کاملThe biosynthesis of spermidine and spermine from putrescine and methionine.
Putrescine, NHz(CH&NHZ, spermidine, NHz(CH&NH(CH&NHt, and sperminc, NH2(CH&NH(CH&NH(CH&NHt, are naturally occurring polyamines (for bibliography see ref. 6). That they have physiological significance is suggested by the following: they have been shown to be essential growth factors for Hemophilus injluenza (7-9) and for a mutant of Aspergillus nidulam (lo), and to stimulate the growth of Lactob...
متن کاملBiosynthesis of the spermidine moiety of glycocinnamoylspermidine antibiotic cinodine.
We have reported in this journal1) the biosynthesis of the glycocinnamoyl moieties of the antibiotic cinodine (Fig. 1), the broad-spectrum antibiotic discovered and identified at the Lederle Laboratories2,3). The glycocinnamoyl moieties were found to originate directly from D-glucosamine and L-tyrosine by isotope incorporation studies. The biosynthesis of the rest of the molecule, i.e., the spe...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44133-1